邓燕近几年工作简介：

 近几年主要从事生物传感和生物芯片的构建，围绕疾病的早期检测诊断、重金属离子和农药的痕量分析等与人类健康相关的问题进行了系统研究，提出采用功能化磁珠筛选高选择性的核酸适配体，并结合信号增强的纳米材料构建高灵敏高选择性高稳定性的检测分析体系。参与获得湖南省自然科学二等奖和教育部科技进步二等奖各一项。发表SCI学术论文100多篇，ESI高被引论文20多篇；获2018、2019和2020年度ESI高被引科学家称号；授权专利2项；承担国家自科基金三项、国家重点研发子项目一项，863、973子项目各一项，及其他省部级项目7项。

近几年承担主持的研究课题：

1、 国家自然科学基金面上项目：基于核酸适配体功能化黑磷纳米片的生物重金属离子信息电化学传感研究（61871180），资助金额：79.2万，2019年01月-2022年12月。主持，正在进行。

2、 国家重点研发计划子项目：核酸适配体和受体蛋白质资源库构建与筛选技术研究（2018YFC1602905），资助金额：70万，2018年12月-2021年12月。主持，正在进行。

3.   国家自然基金面上项目，病原微生物快速高通量检测通用化纳米颗粒芯片技术研究（61471168），2015/01-2018/12，82万，主持，已完成。

4.   国家自然基金面上项目：基于活体微透析技术神经递质动态变化信息微传感器检测的研究（60971045），资助金额：28万，2010年1月-2012年12月。主持，已完成。

5.   国家973计划子项目：生物可降解荧光纳米胶束制备及用于胃癌光学可视化研究（2010CB933903），资助金额： 2011/11-2014/ 12，50万，主持，已完成。

6.   湖南省自然科学基金项目，基于核酸适配体生物体重金属离子快速检测的电化学传感器研究（2017JJ2069），2017/09-2020/09，5万，在研，已完成。

7.   中国博士后特别资助基金项目，生物体重金属离子快速检测的电化学纳米生物传感器研究（2016T90403），2016/03-2017/11，15万，主持，已完成。

8. 江苏省博士后基金项目：病原微生物高通量快速检测通用化纳米芯片技术的研究（1601021A），资助金额：6万，2016年-2017年。主持。正在进行。,

9. 湖南省教育厅重点项目：基于谷氨酸受体癫痫的易感基因及其作用影响的研究（11A030），资助金额：6万，2011年9月-2014月9月，主持，已完成。

10． 湖南省自然科学基金项目：基于活体微透析技术神经递质在线快速检测研究与应用（12JJ6060），资助金额：3万，2012年-2014年。主持，已完成。

11. 中国博士后基金项目：基于活体微透析技术神经递质动态信息微传感器检测研究（2012M520980），资助金额：5万，2011年11年-2013年11月。主持，已完成。

12. 东南大学生物电子学国家重点实验室开放课题：基于活体微透析神经递质信息微传感器检测系统的研究（G10），资助金额：5万，2013年-1015年。主持。已完成。

13. 国家863计划子项目：多孔微电极及生物芯片的构建与应用（2007AA022007），资助金额：26万，2007年6月-2010年12月。主持，已完成。

近五年 研究论文 :

1. Gaojian Yang, Ziqi Xiao, Congli Tang, Yan Deng *, Hao Huang, Ziyu He, Recent advances in biosensor for detection of lung cancer biomarkers, Biosensors and Bioelectronics, 2019, 141: 111416. 

2. Yuan Liu, Yan Deng*, Hongming Dong, Keke Liu, Nongyue He. Progress on sensors based on nanomaterials for rapid detection of heavy metal ions, Science China-Chemistry, 2017, 60(3): 329-337.

3. Lingling Guo, Nongyue He*, Yongxiang Zhao, Tonghua Liu, Yan Deng*, Autophagy modulated by inorganic nanomaterials, Theranostics, 2020, 10(7): 3206-3222.

4. Wenfei Guo, Chuanxiang Zhang, Tingting Ma, Xueying Liu, Zhu Chen, Song Li*, Yan Deng*, Advances in aptamer screening and aptasensors’ detection of heavy metal ions, Journal of Nanobiotechnology, 2021,19: 166. 

5. Gaojian Yang, Yuxuan Lai, Ziqi Xiao, Congli Tang, Yan Deng*. Ultrasensitive electrochemical immunosensor of carcinoembryonic antigen based on gold-label silver-stain signal amplification, Chinese Chemical Letters, 2018, 29, 1857-1860. 

6. Lingling Guo, Hong Chen, Nongyue He*, Yan Deng *. Effects of surface modifications on the physicochemical properties of iron oxide nanoparticles and their performance as anticancer drug carriers, Chinese Chemical Letters, 2018, 29, 1829-1833.

7. Gaojian Yang, Hao Huang, Ziqi Xiao, Chuanxiang Zhang, Wenfei Guo, Tingting Ma, Liang Ma, Zhu Chen∗, and Yan Deng *, A novel strategy for liquid exfoliation of ultrathin black phosphorus nanosheets, Journal of Biomedical Nanotechnology, 2020, 16: 548-552. 

8. Yuan Liu, Yan Deng*, Taotao Li, Zhu Chen, Hui Chen, Song Li, Hongna Liu, Aptamer-based electrochemical biosensor for mercury ions detection using AuNPs-modified glass carbon electrode, Journal of Biomedical Nanotechnology, 2018, 14: 2156-2161. 

9. Yuxuan Lai†, Yan Deng * ,†, Gaojian Yang, Song Li, Chuanxiang Zhang, and Xueying Liu, Molecular Imprinting Polymers Electrochemical Sensor Based on AuNPs/PTh Modified GCE for Highly Sensitive Detection of Carcinomaembryonic Antigen, Journal of Biomedical Nanotechnology, 2018, 14: 1668-1694. 

10. Taotao Li, Huan Yi, Yuan Liu, Zunliang Wang, Sgiquan Liu, Nongyue He*, Hongna Liu, Yan Deng*. One-step synthesis of DNA templated water-soluble Au-Ag bimetallic nanoclusters for ratiometric fluorescence detection of DNA, Journal of Biomedical Nanotechnology, 2018, 14: 150-160. 

11. Yuxuan Lai, Lijun Wang, Yuan Liu, Gaojian Yang, Congli Tang, Yan Deng*, Song Li, Immunosensors based on nanomaterials for detection of tumor markers, Journal of Biomedical Nanotechnology, 2018, 14: 44-65. 

12. Hongna Liu, Hongming Dong, Zhu Chen, Lin Lin, Hui Chen, Song Li*, Yan Deng*. Magnetic nanoparticles enhanced microarray detection of multiple foodborne pathogens, Journal of Biomedical Nanotechnology, 2017, 13, 1333-1343.

13. Tingting Ma, Hao Huang, Wenfei Guo, Chuanxiang Zhang, Zhu Chen, Song Li, Liang Ma*, Yan Deng*, Recent progress in black phosphorus sensors, Journal of Biomedical Nanotechnology, 2020, 16: 1045-1064. 

14. Zhukang Guo, Yuan Liu, Nongyue He*, Yan Deng*, LianJin*, Discussion of the protein characterization techniques used in the identification of membrane protein targets corresponding to tumor cell aptamers, Chinese Chemical Letters, 2021, 32(1), 40-47. 

15. Li Huang, Enben Su, Yuan Liu, Nongyue He*, Yan Deng*, Lian Jin*, Zhu Chen, Song Li, A microfluidic device for accurate detection of hs-cTnI, Chinese Chemical Letters, 2021, 32, 1555-1558. 

16. Yuan Liu, Gaojian Yang, Taotao Li, Yan Deng*, Zhu Chen, Nongyue He*, Selection of a DNA aptamer for the development of fluorescent aptasensor for carbaryl detection, Chinese Chemical Letters, 2021, 32, 1957-1962. 

17. Mei Liu, Biao Zhang, Zhiyang Li, Zhifei Wang*, Song Li, Hongna Liu, Yan Deng*, Nongyue He*, Precise discrimination of Luminal A breast cancer subtype using an aptamer in vitro and in vivo, Nanoscale, 2020, DOI: 10.1039/d0nr03324c. 

18. Yujie Tang, Hongna Liu, Hui Chen, Zhu Chen, Yuan Liu, Lian Jin*, Yan Deng ∗, Song Li∗, Nongyue He∗, Advances in aptamer screening and drug delivery, Journal of Biomedical Nanotechnology, 2020, 16: 763-788. 

19. Jinrong Chen, Shihao Zhang, Yuhan Wang, Ruwen Xie, Lishang Liu*, Yan Deng *, In vivo self-assembly based cancer therapy strategy, Journal of Biomedical Nanotechnology, 2020, 16: 997-1017. 

20. Yuxuan Lai, Chuangxiang Zhang, Yan Deng*, Gaojian Yang, Song Li, Congli Tang, Nongyue He*, A novel α-fetoprotein-MIP immunosensor based on AuNPs/PTh modified glass carbon electrode, Chinese Chemical Letters, 2019, 30, 160-162. 

21. Mei Liu, Arshad Khan, Zhifei Wang, Yuan Liu, Gaojian Yang, Yan Deng*, Nongyue He*, Aptasensors for pesticide detection, Biosensors and Bioelectronics, 2019, 130: 174-184.

22. Yuxuan Lai, Hao Huang, Zhihuan Xia, Song Li, Yan Deng*, Xueying Liu*, A sandwich-type electrochemical immunosensor using polythionine/AuNPs nanocomposites as label for ultrasensitive detection of carcinoembryonic antigen, Materials Express, 2019, 9(5): 444-450. 

23. Xiaocheng Yu, Lei He, Myima Pentok, Haowen Yang, Yale Yang, Zhiyang Li, Nongyue He*, Yan Deng*, Song Li, Tonghua Liu*, Xiangyu Chen, Huiwen Luo, An aptamer-based new method for competitive fluorescence detection of exosomes, Nanoscale, 2019, 11, 15589–15595. 

24. Xianbo Mou∗, Zhu Chen, Taotao Li, Mei Liu, Yuan Liu, Zeeshan Ali, Song Li, Yabin Zhu, Zhiyang Li, and Yan Deng*, A Highly Sensitive Strategy for Low-Abundance Hepatitis B Virus Detection via One-Step Nested Polymerase Chain Reaction, Chemiluminescence Technology and Magnetic Separation, Journal of Biomedical Nanotechnology, 2019, 15, 1832–1838.

25. Yuan Liu, Taotao Li, Chuxuan Ling, Zunliang Wang, Lian Jin, Yongxiang Zhao, Zhu Chen, Song Li, Yan Deng*, Nongyue He*, A simple visual method for DNA detection based on the formation of gold nanoparticles, Chinese Chemical Letters, 2019, 30, 2359-2362.

26. Yuan Liu, Taotao Li, Chuxuan Ling, Zhu Chen, Yan Deng*, Nongyue He*, Electrochemical sensor for Cd2+ andPd2+ detection based on Nano-porous pseudo carbon paste electrode, Chinese Chemical Letters, 2019, 30, 2211-2215. 

27. Lian Jin†, Yan Deng †, Nongyue He, Lijun Wang, and Mengling Weng . Polyethylenimine-Mediated CCR5 Gene Knockout Using Transcription Activator-LikeEffector Nucleases,Journal of Biomedical Nanotechnology, 2018, 14: 546–552. 

28. Rasheed Ahmad, Yan Deng *, Ravina Singh, Mubashir Hussain, Muhammad Ali Abdullah Shah, Sauli Elingarami, Nongyue He*, Yueming Sun. Cutting edge protein and carbohydrate-based materials for anticancer drug delivery, Journal of Biomedical Nanotechnology, 2018, 14: 20-43. 

29. Yuan Liu, Yuxuan Lai, Gaojian Yang, Congli Tang, Yan Deng*, Song Li*, Zunliang Wang. Cd-aptamer electrochemical biosensor based on AuNPs/CS modified glass carbon electrode, Journal of Biomedical Nanotechnology, 2017, 13, 1253-1259. 

30. Rongrong Huang, Zhongsi Chen, Mei Liu,  Yan Deng*, Song Li, Nongyue He*, The aptamers generated from HepG2 cells, Science China-Chemistry, 2017, 60(6): 786-792. 

31. Bo Li, Xianbo Mou, Zhu Chen, Hui Chen, Yan Deng*, Song Li, Enben Su, Lei He, Nongyue He*. The decelop of a repid high-quality universal nucleic acid extraction kit based on magnetic separation, Science China-Chemistry, 2017, 60(12): 1602-1608. 

32. Hui Chen, Yanqi Wu, Zhu Chen, Zhili Hu, Yile Fang, Pei Liao, Yan Deng*, Nongyue He*, Performance evaluation of a novel sample in-answer out(SIAO) system based on magnetic nanoparticles, Journal of Biomedical Nanotechnology, 2017, 13, 1619-1630. 

33.  Yan Deng*, Keke Liu, Yuan Liu, Hongming Dong, Song Li, An Novel Acetylcholinesterase Biosensor Based on Nano-porous Pseudo Carbon Paste Electrode Modified with Gold Nanoparticles For Detection of Methyl Parathion, J Nanosci Nanotechnol, 2016, 16(9), 9460-9467.

34. Keke Liu, Hongming Dong, Yan Deng *. Recent advances on rapid detection of pesticides based on enzyme biosensor of nanomaterials, J Nanosci Nanotechnol, 2016, 16(7), 6648-6656.

35. Jun Yu, Zhu Chen, Chao Wang, Yana Hu, Hongming Dong, Yan Deng*. Design and implementation of experimental consumable management device for the automatic nucleic acid detection system, J. Nanosci. Nanotechnol. 2016, 16(7), 7069-7076.

36. Chao Wang, He Zhu, Zhu Chen, Yan Deng*, Enben Su, Pengfeng Xiao. Control methods of mechanical arms motion for automatic nucleic acid detection system based on magnetic nanoparticles, J. Nanosci. Nanotechnol. 2016, 16(12), 12455-12459.

37. 32. Hui Chen, Yang Wu, Zhu Chen, Xianbo Mou, Zhiyang Li, Enben Su, Yan Deng*, Nongyue He*. From sample to answer: a low-cost disposable cartridge for epidemic detection on site based on 3D printing technology, Nanoscience and Nanotechnology Letters, 2016, 8, 1118-1126.

38. 33. Yuan Liu, Keke Liu, Hongming Dong, Liming Zhang*, Yan Deng*, Chao Ma, Zunliang Wang. Acetylcholinesterase biosensor for carbaryl detection based on nano-porous pseudo carbon paste electrode, Nanoscience and Nanotechnology Letters, 2016, 8, 785-790.

39. Xianbo Mou, Zeeshan Ali, Bo Li, Taotao Li, Huan Yi, Hongming Dong, Nongyue He*, Yan Deng*, Xin Zeng*. Multiple genotyping based on multiplex PCR and microarray, Chinese Chemical Letters, 2016, 27(11), 1661-1665.